Alabama researchers energize efforts to aid search for COVID-19 therapies

Alabama researchers energize efforts to aid search for COVID-19 therapies
Researchers in Oregon are using Birmingham-based TriAltus Bioscience's protein purification technology to accelerate research into a new COVID-19 vaccine. (TriAltus)

Alabama’s bioscience researchers and organizations have mobilized to combat the COVID-19 pandemic, helping to advance urgent work that could lead to new treatments and vaccines.

This includes Birmingham-based TriAltus Bioscience LLC, which developed protein purification technology to support research into a new COVID-19 vaccine under development at the Earle A. Chiles Research Institute in Portland, Oregon.

Institute researchers are using the TriAltus CL7/lm7 system to isolate and purify the distinctive Spike protein, or S-protein, that helps the COVID-19 virus attach to and infect human cells.

“We’re in a race to develop this vaccine as quickly as possible, so it’s important to have technology that helps us isolate and purify the S-protein for time-critical research,” said Dr. Hong-Ming Hu, a scientist at the Earle A. Chiles Research Institute at the Providence Cancer Institute.

Hu’s team is fast-tracking the development of the potential vaccine, with trials possibly beginning in May.

“It’s rewarding to know that our product can help expedite the search for a COVID-19 vaccine,” TriAltus CEO Bob Shufflebarger said.

The CL7 technology was invented by a team led by Dr. Dmitry Vassylyev, TriAltus co-founder and professor of biochemistry and molecular biology at the University of Alabama at Birmingham (UAB).

Technology developed by Birmingham’s TriAltus Bioscience is being used to speed development of a potential COVID-19 vaccine at the Earle A. Chiles Research Institute in Oregon. (contributed)

 

Targeting a treatment

In Huntsville, a collaboration aims to learn how the human immune system responds to the SARS-CoV-2 virus, which causes COVID-19, with hopes for developing an effective treatment for the disease.

Teaming in the effort are Huntsville Hospital, the HudsonAlpha Institute for Biotechnology and iRepetroire, a diagnostic technology company on the HudsonAlpha campus.

“The most effective way to stop pandemics is with vaccines,” said Dr. Rick Myers, president and scientific director for HudsonAlpha. “However, the pipeline for vaccine production from development, to testing, to market can take years. A COVID-19 treatment is the best way to bridge the gap until a vaccine is widely available.”

Researchers at HudsonAlpha and iRepertoire hope the results of the study can be used to find and test possible treatments or cures for COVID-19 by using antibodies identified in patients diagnosed with COVID-19.

“The immune system is nature’s best doctor,” said Dr. Jian Han, founder and chief scientific officer of iRepertoire. “By understanding the immune system of patients that have effectively fought the pathogen, we can pinpoint the exact identity of cells that effectively eliminate the virus out of millions of possibilities.”

Accelerating timelines

Involved in this battle on many fronts, UAB reported that it has raised more than $1.1 million for clinical and basic research focused on the novel coronavirus and COVID-19.

UAB researchers are involved in several projects as part of the effort against COVID-19. (UAB)

The money was dedicated to clinical research and basic research projects proposed by UAB faculty in the School of Medicine. Fifty-two proposals were submitted, with 14 basic science projects selected for funding, with help from UAB’s Hugh Kaul Precision Medicine Institute.

“Because of the urgency of this pandemic, one of the criteria was how quickly the research team could launch their study and how quickly they could begin to see results,” said Dr. Etty (Tika) Benveniste, senior vice dean for Basic Sciences at UAB.

“We wanted research studies that could be reviewed at the three- and six-month time frames to determine their potential. That is a very accelerated timeline for research.”

UAB is also participating in a global clinical trial of potential COVID-19 treatments, including remdesivir, which has received emergency FDA approval as a therapeutic agent against the virus.

In addition, UAB and Birmingham’s Southern Research are collaborating with Scripps Research to test drugs that could be effective against COVID-19.

This story originally appeared on the Alabama Department of Commerce’s Made in Alabama website.

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