Oxford-AstraZeneca COVID-19 vaccine study shows dual immune action

Oxford-AstraZeneca COVID-19 vaccine study shows dual immune action
A researcher at AstraZeneca. AstraZeneca is working with the University of Oxford on a COVID-19 vaccine that is entering final-stage testing. (AstraZeneca)

A coronavirus vaccine the University of Oxford is developing with AstraZeneca Plc showed promising results in early human testing, which is a sign of progress in the high-stakes pursuit of a shot to defeat the pathogen.

The vaccine increased levels of protective neutralizing antibodies and immune T-cells that target the virus, according to the study organizers. The results were published Monday in The Lancet medical journal.

AstraZeneca shares rose as much as 10% in London but gave up much of the gain to trade 0.6% higher as researchers cautioned that the results are preliminary. A positive outcome had been widely expected after reports last week lifted the stock, with the vaccine already in more advanced trials.

Researchers are finding promising results with drug testing against COVID-19. (Getty Images)

“We are seeing very good immune responses, not just on neutralizing antibodies but of T-cells as well,” said Adrian Hill, head of Oxford’s Jenner Institute. “We’re stimulating both arms of the immune system.”

The results will be closely scrutinized as governments around the world seek to end a pandemic that’s killed more than 600,000 people and triggered economic turmoil since erupting this year. Moderna Inc., another front-runner, released results last week from an early-stage test that showed its vaccine raised levels of antibodies that fight the virus.

Key step

Although stimulating production of neutralizing antibodies doesn’t prove a vaccine will be effective, it’s considered an important early step in testing. Results from testing in animals had already shown the Oxford-AstraZeneca shot provoked an immune response.

Across the world, about 160 coronavirus vaccines are in various stages of development, according to the World Health Organization. The Oxford shot is close to the front of the pack and has already begun final-stage tests. AstraZeneca has said it may begin delivering doses to the U.K. as early as September.

“We want other companies to have vaccines that work as well because the world will get more vaccine sooner,” Hill said. “We just feel there is an advantage of having both arms of the immune system stimulated well.”

The Old Road Campus of Oxford University, which houses the Jenner Institute. A research team from the Jenner Institute, led by Sarah Gilbert – professor of Vaccinology at University of Oxford – are designing a vaccine for COVID-19 and are close to starting human trials. (Visionhaus/Getty Images Europe)

The British drugmaker received a boost when the U.S. pledged as much as $1.2 billion toward development. Under its agreement with Astra, the U.S. could begin receiving supplies as early as October.

The U.K. has also struck a supply agreement for the shot, but on Monday it secured access to other drugmakers’ experimental vaccines to hedge its bets and garner enough doses to cover its population of 66 million. The government secured deals with Pfizer Inc., BioNTech SE and Valneva SE.

COVID-19 fight

Companies and universities are relying on an array of approaches in the fight against COVID-19. The Oxford team has developed a technology that can speed the process by using a harmless virus to carry some of the pathogen’s genetic material into cells to generate an immune response. The proposed vaccine is made from a weakened version of a common cold virus that’s genetically changed to make it unable to grow in humans.

Oxford has inserted genetic material from the surface spike protein of the SARS-CoV-2 virus as a way of tricking the immune system into fighting back. The platform stimulates both antibodies and high levels of killer T-cells, a type of white blood cell that helps the immune system destroy infection.

“We’re very encouraged,” Hill said. While the test doesn’t prove the vaccine will work, “I think we’re a bit more confident it should work this week than last week.”

Researchers at AstraZeneca are working with the University of Oxford on a COVID-19 vaccine. (AstraZeneca)

Moderna’s initial results were from the first group of 45 patients who received the vaccine. Moderna’s shares surged in U.S. trading after the results, despite a high rate of side effects among patients who got the shot.

The Oxford shot elicited neutralizing antibodies after a single dose, Hill said. That may be an important advantage in quickly raising immunity.

“I don’t read that clearly in the Moderna data,” he said. “I think they need two doses to see plausibly protective neutralizing antibodies.”

A large trial is set to begin this month that will test Moderna’s vaccine in a two-shot regimen. Astra will also prioritize a two-shot regimen, Hill said.

“It gives higher titres of antibodies, which is important going forward,” he said.

(Contact the reporters at [email protected] and [email protected].)

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